A miniature mimic of host defense peptides with systemic antibacterial efficacy.

@article{Sarig2010AMM,
  title={A miniature mimic of host defense peptides with systemic antibacterial efficacy.},
  author={Hadar Sarig and Liran Livne and Victoria Held-Kuznetsov and Fadia Zaknoon and Andrey Ivankin and David Gidalevitz and Amram Mor},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2010},
  volume={24 6},
  pages={1904-13}
}
Oligomers of acylated lysines (OAKs) are synthetic mimics of host defense peptides (HDPs) with promising antimicrobial properties. Here we challenged the OAK concept for its ability to generate both systemically efficient and economically viable lead compounds for fighting multidrug-resistant bacteria. We describe the design and characterization of a miniature OAK composed of only 3 lysyls and 2 acyls (designated C(12(omega7))K-beta(12)) that preferentially targets gram-positive species by a… CONTINUE READING