A mild treatment strategy for in-vitro fertilisation: a randomised non-inferiority trial

@article{Heijnen2007AMT,
  title={A mild treatment strategy for in-vitro fertilisation: a randomised non-inferiority trial},
  author={Esther Heijnen and Marinus J. C. Eijkemans and Cora de Klerk and Suzanne Polinder and Nicole G.M. Beckers and Ellen R Klinkert and Frank J M Broekmans and Jan Passchier and Egbert R. te Velde and Nicholas S. Macklon and Bart C. J. M. Fauser},
  journal={The Lancet},
  year={2007},
  volume={369},
  pages={743-749}
}
BACKGROUND Mild in-vitro fertilisation (IVF) treatment might lessen both patients' discomfort and multiple births, with their associated risks. We aimed to test the hypothesis that mild IVF treatment can achieve the same chance of a pregnancy resulting in term livebirth within 1 year compared with standard treatment, and can also reduce patients' discomfort, multiple pregnancies, and costs. METHODS We did a randomised, non-inferiority effectiveness trial. 404 patients were randomly assigned… Expand

Paper Mentions

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ConditionsAneuploidy, Infertility, Infertility, Female
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Interventional Clinical Trial
Women with compromised ovarian reserve requiring in vitro fertilization (IVF) still represent a demanding challenge for clinicians. It has classically been claimed that using higher… Expand
ConditionsInfertility
InterventionDrug
Cost-effectiveness of a mild compared with a standard strategy for IVF: a randomized comparison using cumulative term live birth as the primary endpoint.
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It is unlikely, over a wide range of society's willingness-to-pay, that the standard treatment strategy is cost-effective, compared with the mild strategy, despite an increased mean number of IVF cycles within 1 year. Expand
Mild Ovarian Stimulation for in vitro Fertilization: Are We Ready to Change? A Meta-Analysis
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This analysis presents strong evidence in favour of conventional stimulation IVF, which therefore should currently be considered a treatment of choice for patients requiring IVF treatment. Expand
Minimal stimulation IVF vs conventional IVF: a randomized controlled trial.
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Compared with conventional in vitro fertilization with double embryo transfer, mini-in vItro fertilized with single embryo transfer lowers live birth rates, completely eliminates ovarian hyperstimulation syndrome, reduces multiple pregnancy rates, and reduces gonadotropin consumption. Expand
Minimal Stimulation In Vitro Fertilization: A Better Outcome
  • A. Datta
  • Medicine
  • International journal of fertility & sterility
  • 2016
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A large retrospective cohort study from Japan using a protocol comprising of extended CC and low-dose gonadotropin and subsequent single vitrified-thawed ET found the treatment outcomes of in all age-groups were comparable with those in the Registry of the Society for Assisted Reproduction in the USA. Expand
[Are mild ovarian stimulations for IVF-ET a significant progress in assisted reproductive technologies?].
TLDR
There is insufficient scientific evidence to shift from standard stimulation to mild stimulation for all patients, so cultural standards have to be considered in the choice of the type of stimulation. Expand
Mild stimulation for in vitro fertilization.
TLDR
Although equally effective, mild-stimulation IVF is associated with a greater safety profile, in terms of the incidence of ovarian hyperstimulation syndrome and venous thromboembolism, and is found to be better tolerated by patients and less expensive. Expand
Mild versus conventional ovarian stimulation for IVF in poor, normal and hyper-responders: a systematic review and meta-analysis
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It may be time to recommend mild-dose ovarian stimulation for IVF for all categories of women i.e. hyper, poor and normal responders to IVF with reassurance on using MD-IVF not only for the LBR per cycle but also for the cumulative LBR, with moderate QoE. Expand
The clinical significance of the retrieval of a low number of oocytes following mild ovarian stimulation for IVF: a meta-analysis.
TLDR
After mild ovarian stimulation, a modest number of oocytes is associated with optimal implantation rates and does not reflect a poor ovarian response, therefore, the fear of reducing the number of Oocytes retrieved following mild ovarian stimulating appears to be unjustified. Expand
Improving the patient's experience of IVF/ICSI: a proposal for an ovarian stimulation protocol with GnRH antagonist co-treatment.
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To facilitate the implementation of treatments that optimize the patient's experience, a simple GnRH antagonist protocol for use in predicted normal responders is proposed. Expand
Potential Benefit of Mild Stimulation Regimen on Embryo Quality in IVF- ICSI Cycles
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In a specific subgroup of women with poor embryo quality following conventional IVF-ICSI protocols, a mild stimulation regimen seems to improve embryo quality. Expand
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