A mild and efficient one-pot synthesis of 2-dihydroimidazoles from aldehydes

@article{Fujioka2005AMA,
  title={A mild and efficient one-pot synthesis of 2-dihydroimidazoles from aldehydes},
  author={Hiromichi Fujioka and Kenichi Murai and Yusuke Ohba and Atsushi Hiramatsu and Yasuyuki Kita},
  journal={Tetrahedron Letters},
  year={2005},
  volume={46},
  pages={2197-2199}
}
Abstract The reactions of various aldehydes and 1,2-diamines followed by NXS treatment proceed at 0 °C–rt to give the corresponding dihydroimidazoles in high yields. The reaction is mild, and many functional groups such as halogens, nitriles, and esters can exist. 
74 Citations
A Mild and Efficient One‐Pot Synthesis of 2‐Dihydroimidazoles from Aldehydes.
Abstract The reactions of various aldehydes and 1,2-diamines followed by NXS treatment proceed at 0 °C–rt to give the corresponding dihydroimidazoles in high yields. The reaction is mild, and manyExpand
Efficient, Rapid and One Pot Synthesis of 2-substituted Benzimidazoles Using the NaOH/I2 System as an Oxidant Under Mild Conditions
A one-pot efficient synthesis of benzimidazole derivatives has been achieved from aryl aldehydes and o-phenylenediamine in the presence of the NaOH/I2 system at room temperature in acetonitrile. TheExpand
One-pot synthesis of imidazolines from aldehydes: detailed study about solvents and substrates
Abstract Imidazolines were prepared in one-pot operation from aldehydes and diamines through oxidation of aminal intermediates by NBS. This method could be applied to various aromatic and aliphaticExpand
[Development and application of practical synthetic methods of imidazolines].
  • Kenichi Murai
  • Chemistry, Medicine
  • Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
  • 2010
TLDR
The first method to prepare imidazolines from aldehydes and 1,2-diamines by condensation and successive oxidation using NBS in one-pot operation is described. Expand
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