A microtubule-binding Rho-GEF controls cell morphology during convergent extension of Xenopus laevis.

@article{Kwan2005AMR,
  title={A microtubule-binding Rho-GEF controls cell morphology during convergent extension of Xenopus laevis.},
  author={Kristen M. Kwan and Marc W Kirschner},
  journal={Development},
  year={2005},
  volume={132 20},
  pages={4599-610}
}
During Xenopus development, convergent extension movements mediated by cell intercalation drive axial elongation. While many genes required for convergent extension have been identified, little is known of regulation of the cytoskeleton during these cell movements. Although microtubules are required for convergent extension, this applies only to initial stages of gastrulation, between stages 10 and 10.5. To examine the cytoskeleton more directly during convergent extension, we visualized actin… CONTINUE READING

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