A microtubule-associated protein (MAP2) kinase restores microtubule motility in embryonic brain.

@article{Lopez1995AMP,
  title={A microtubule-associated protein (MAP2) kinase restores microtubule motility in embryonic brain.},
  author={Leonardo A. Lopez and Michael P Sheetz},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 21},
  pages={12511-7}
}
Motility driven by the microtubule motors, kinesin and cytoplasmic dynein, is inhibited by MAP2 (López, L. A., and Sheetz, M. P. (1993) Cell Motil. Cytoskeleton 24, 1-16). The MAP2 inhibition is reversed by a kinase that is co-purified with chicken embryonic MAP2, completely releasing MAP2 from the microtubules. We have identified this activity with a kinase, embryonic MAP2 kinase (M(r) = 100,000), which phosphorylates MAP2 at serine amino acid residues. This kinase is c-AMP independent and… CONTINUE READING

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