A microscale human liver platform that supports the hepatic stages of Plasmodium falciparum and vivax.

@article{March2013AMH,
  title={A microscale human liver platform that supports the hepatic stages of Plasmodium falciparum and vivax.},
  author={Sandra B March and Shengyong Ng and Soundarapandian Velmurugan and Ani Galstian and Jing Shan and David J. Logan and Anne E. Carpenter and David H Thomas and Betty Kim Lee Sim and Maria M Mota and Stephen L Hoffman and Sangeeta N. Bhatia},
  journal={Cell host & microbe},
  year={2013},
  volume={14 1},
  pages={104-15}
}
The Plasmodium liver stage is an attractive target for the development of antimalarial drugs and vaccines, as it provides an opportunity to interrupt the life cycle of the parasite at a critical early stage. However, targeting the liver stage has been difficult. Undoubtedly, a major barrier has been the lack of robust, reliable, and reproducible in vitro liver-stage cultures. Here, we establish the liver stages for both Plasmodium falciparum and Plasmodium vivax in a microscale human liver… CONTINUE READING

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Gene disruption of Plasmodium falciparum p52 results in attenuation of malaria liver stage development in cultured primary human hepatocytes

  • BC van Schaijk, CJ Janse, +7 authors SL Hoffman
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