A microsatellite repeat in the promoter of the N-methyl-D-aspartate receptor 2A subunit (GRIN2A) gene suppresses transcriptional activity and correlates with chronic outcome in schizophrenia.

@article{Itokawa2003AMR,
  title={A microsatellite repeat in the promoter of the N-methyl-D-aspartate receptor 2A subunit (GRIN2A) gene suppresses transcriptional activity and correlates with chronic outcome in schizophrenia.},
  author={Masanari Itokawa and Kiyofumi Yamada and Kiyoshi Yoshitsugu and Tomoko Toyota and Toshiro Suga and Hisako Ohba and Akiko Watanabe and Eiji Hattori and Hiromitsu Shimizu and Tetsuo Kumakura and Mitsuru Ebihara and Joanne M A Meerabux and Michio Toru and Takeo Yoshikawa},
  journal={Pharmacogenetics},
  year={2003},
  volume={13 5},
  pages={271-8}
}
Hypofunction of the N-methyl-D-aspartate (NMDA) receptor has been hypothesized to underlie the pathophysiology of schizophrenia, based on the observation that non-competitive antagonists of the NMDA receptor, such as phencyclidine, induce schizophrenia-like symptoms. Mice lacking the NR2A subunit of the NMDA receptor complex are known to display abnormal behaviour, similar to schizophrenic symptoms. The expression of NR2A starts at puberty, a period corresponding to the clinical onset of… CONTINUE READING
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