A micromethod for the in vitro micronucleus assay.

@article{Nesslany1999AMF,
  title={A micromethod for the in vitro micronucleus assay.},
  author={Fabrice Nesslany and Daniel Marzin},
  journal={Mutagenesis},
  year={1999},
  volume={14 4},
  pages={403-10}
}
A micromethod for the in vitro micronucleus assay was developed using L5178Y cells to enable the rapid screening of a large number of molecules. The method is quick, simple to perform and needs very small amounts of compound, i.e. <10 mg. In this methodology, three types of treatment were carried out in parallel, enabling an optimal detection of both aneugenic and clastogenic compounds: two treatments without metabolic activation with or without a recovery period after a 24 h continuous… CONTINUE READING

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