A micromethod for the determination of globin synthetic ratios (GSR): 94

@article{Constantsas1980AMF,
  title={A micromethod for the determination of globin synthetic ratios (GSR): 94},
  author={N Constantsas and J Palis and C Dacou-Voutetakis},
  journal={Pediatric Research},
  year={1980},
  volume={14},
  pages={180}
}
The GSR is an absolute criterion for diagnosis, investigation, and classification of thalassemias (thal). Its wide use is prevented by the tedious, time consuming processing of the numerous fractions obtained by conventional column chromatography. Electrophoresis is simpler, but gret dilution of the "hot" globin (newly synthesized by retics) in the "cold" hemoglobin of the mature red cells, results in unreliably low radioactivity of the separated globin bands. This can be overcome only by… CONTINUE READING