A microfluidic culture platform for CNS axonal injury, regeneration and transport

@article{Taylor2005AMC,
  title={A microfluidic culture platform for CNS axonal injury, regeneration and transport},
  author={Anne Marion Taylor and Mathew Blurton-Jones and Seog Woo Rhee and David Hastings Cribbs and Carl Cotman and Noo Li Jeon},
  journal={Nature Methods},
  year={2005},
  volume={2},
  pages={599-605}
}
Investigation of axonal biology in the central nervous system (CNS) is hindered by a lack of an appropriate in vitro method to probe axons independently from cell bodies. Here we describe a microfluidic culture platform that polarizes the growth of CNS axons into a fluidically isolated environment without the use of targeting neurotrophins. In addition to its compatibility with live cell imaging, the platform can be used to (i) isolate CNS axons without somata or dendrites, facilitating… CONTINUE READING
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