A microfluidic chip-compatible bioassay based on single-molecule detection with high sensitivity and multiplexing.

@article{Burton2010AMC,
  title={A microfluidic chip-compatible bioassay based on single-molecule detection with high sensitivity and multiplexing.},
  author={Randall E Burton and Eric J White and Ted R. Foss and Kevin M. Phillips and Robert H Meltzer and Nanor Kojanian and Lisa W Kwok and Alex J. X. Lim and Nancy L Pellerin and Natalia V Mamaeva and Rudolf Gilmanshin},
  journal={Lab on a chip},
  year={2010},
  volume={10 7},
  pages={843-51}
}
Many applications in pharmaceutical development, clinical diagnostics, and biological research demand rapid detection of multiple analytes (multiplexed detection) in a minimal volume. This need has led to the development of several novel array-based sensors. The most successful of these so far have been suspension arrays based on polystyrene beads. However, the 5 microm beads used for these assays are incompatible with most microfluidic chip technologies, mostly due to clogging problems. The… CONTINUE READING

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