A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices.

@article{Midwoud2010AMA,
  title={A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices.},
  author={Paul M van Midwoud and Marjolijn T. Merema and E Verpoorte and Geny M M Groothuis},
  journal={Lab on a chip},
  year={2010},
  volume={10 20},
  pages={
          2778-86
        }
}
Over the past two decades, it has become increasingly clear that the intestine, in addition to the liver, plays an important role in the metabolism of xenobiotics. Previously, we developed a microfluidic-based in vitro system for the perifusion of precision-cut liver slices for metabolism studies. In the present study, the applicability of this system for the perifusion of precision-cut intestinal slices, and for the sequential perifusion of intestinal and liver slices, all from rat, was tested… CONTINUE READING

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