A microfabricated array bioreactor for perfused 3D liver culture.

  title={A microfabricated array bioreactor for perfused 3D liver culture.},
  author={Mark J Powers and Karel Domansky and Mohammad R. Kaazempur-Mofrad and Artemis Kalezi and Adam T Capitano and Arpita Upadhyaya and Petra Kurzawski and Kathryn E Wack and Donna B Stolz and Roger Kamm and Linda G Griffith},
  journal={Biotechnology and bioengineering},
  volume={78 3},
We describe the design, fabrication, and performance of a bioreactor that enables both morphogenesis of 3D tissue structures under continuous perfusion and repeated in situ observation by light microscopy. Three-dimensional scaffolds were created by deep reactive ion etching of silicon wafers to create an array of channels (through-holes) with cell-adhesive walls. Scaffolds were combined with a cell-retaining filter and support in a reactor housing designed to deliver a continuous perfusate… CONTINUE READING
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