A microenvironment, rather than chemical, initiates the cardiomyogenic differentiation of marrow stromal cells

@article{Weixin2008AMR,
  title={A microenvironment, rather than chemical, initiates the cardiomyogenic differentiation of marrow stromal cells},
  author={Liu Wei-xin and Song Jian and Wan Xian Yu and Pan Guo-dong and Liu Yu and Cheng Bang-chang and Chen Xi-chang},
  journal={Wuhan University Journal of Natural Sciences},
  year={2008},
  volume={9},
  pages={513-521}
}
To investigate the potential of cardiomyogenic differentiation of rat bone marrow stromal cells (MSCs), they were exposed to 5-azacytidine tretments (single/repeat) at varying concentrations (3, 5, 10 μmol/L) and the fates of the cells were analyzed by immunocytochemistry, Western blot and the reporter gene of enhanced cyan fluorescent protein (ECFP) under the control of ventricular myosin light chain 2 (MLC2v) promoter. MSCs were also cocultured with cardiomyocytes for periods up to 16 days… CONTINUE READING

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