A microdialysis study of ST1936, a novel 5-HT6 receptor agonist

@article{Valentini2011AMS,
  title={A microdialysis study of ST1936, a novel 5-HT6 receptor agonist},
  author={Valentina Valentini and Roberto Frau and Fabio Bordi and Franco Borsini and Gaetano di Chiara},
  journal={Neuropharmacology},
  year={2011},
  volume={60},
  pages={602-608}
}
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Effects of ST1936, a selective serotonin-6 agonist, on electrical activity of putative mesencephalic dopaminergic neurons in the rat brain
TLDR
In-vivo electrophysiological studies investigate the physiological role of 5-HT6 receptors in the control of the function of the substantia nigra pars compacta and ventral tegmental area of anesthetised rats and demonstrate the need for further investigations into the use of 4- HT6 receptor agonists to control cognitive disfunction.
Evidence for a role of a dopamine/5-HT6 receptor interaction in cocaine reinforcement
The 5-hydroxytryptamine (serotonin) receptor 6 agonist EMD 386088 ameliorates ketamine-induced deficits in attentional set shifting and novel object recognition, but not in the prepulse inhibition in rats
TLDR
The beneficial effects of the 5-HT6 agonist in ameliorating some of the ketamine-induced deficits relevant to schizophrenia seem likely to represent a useful pharmacological approach to the treatment of cognitive disturbances observed in this disorder.
Study of a mechanism responsible for potential antidepressant activity of EMD 386088, a 5-HT6 partial agonist in rats
TLDR
Behavioral data seem to confirm the importance of dopaminergic system activation in antidepressant-like activity of EMD386088, since this effect, observed in the FST, was abolished by the preferential D1- and D2-like receptor subfamily antagonists SCH23390 and sulpiride, respectively.
ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of cloned human 5-HT6 receptors.
Effects of the 5-HT6 receptor agonist ST 1936 on depression- and anhedonia-like experimental models
Behavioral and neurochemical pharmacology of 5-HT6 receptors related to reward and reinforcement.
Antidepressant-like activity of EMD 386088, a 5-HT6 receptor partial agonist, following systemic acute and chronic administration to rats
TLDR
The obtained findings suggest that EMD 386088 produces antidepressant-like activity after systemic acute and chronic administration which may result from direct stimulation of 5-HT6 receptors.
Serotonergic modulation of the activity of mesencephalic dopaminergic systems: Therapeutic implications
Serotonergic modulation of the activity of mesencephalic dopaminergic systems: Therapeutic implications.
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References

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