A microRNA expression signature of human solid tumors defines cancer gene targets.

@article{Volinia2006AME,
  title={A microRNA expression signature of human solid tumors defines cancer gene targets.},
  author={Stefano Volinia and George A. Calin and Chang-gong Liu and Stefan Ambs and Amelia Cimmino and Fabio Petrocca and Rosa Visone and Marilena V. Iorio and Claudia Roldo and Manuela Ferracin and Robyn L. Prueitt and Nozumu Yanaihara and Giovanni Lanza and Aldo Scarpa and Andrea Vecchione and Massimo Negrini and Curtis C. Harris and Carlo M Croce},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 7},
  pages={
          2257-61
        }
}
Small noncoding microRNAs (miRNAs) can contribute to cancer development and progression and are differentially expressed in normal tissues and cancers. From a large-scale miRnome analysis on 540 samples including lung, breast, stomach, prostate, colon, and pancreatic tumors, we identified a solid cancer miRNA signature composed by a large portion of overexpressed miRNAs. Among these miRNAs are some with well characterized cancer association, such as miR-17-5p, miR-20a, miR-21, miR-92, miR-106a… CONTINUE READING

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