A microRNA-27a mimic sensitizes human oral squamous cell carcinoma HSC-4 cells to hyperthermia through downregulation of Hsp110 and Hsp90.

@article{Kariya2014AMM,
  title={A microRNA-27a mimic sensitizes human oral squamous cell carcinoma HSC-4 cells to hyperthermia through downregulation of Hsp110 and Hsp90.},
  author={Ayako Kariya and Yukihiro Furusawa and Tatsuya Yunoki and Takashi Kondo and Yoshiaki Tabuchi},
  journal={International journal of molecular medicine},
  year={2014},
  volume={34 1},
  pages={334-40}
}
Hyperthermia (HT) is an important modality in cancer treatment; however, the acquisition of thermal resistance in cancer cells due to the elevation of heat shock proteins (HSPs) makes HT less effective. Accumulating evidence suggests that microRNAs (miRNAs) play an important role in regulating cellular stress sensitivities, such as drug sensitivity and… CONTINUE READING