A microRNA-21 surge facilitates rapid cyclin D1 translation and cell cycle progression in mouse liver regeneration.

@article{Ng2012AMS,
  title={A microRNA-21 surge facilitates rapid cyclin D1 translation and cell cycle progression in mouse liver regeneration.},
  author={Raymond W P Ng and Guisheng Song and Garrett R. Roll and Niels M. Frandsen and Holger Willenbring},
  journal={The Journal of clinical investigation},
  year={2012},
  volume={122 3},
  pages={1097-108}
}
MicroRNA-21 (miR-21) is thought to be an oncomir because it promotes cancer cell proliferation, migration, and survival. miR-21 is also expressed in normal cells, but its physiological role is poorly understood. Recently, it has been found that miR-21 expression is rapidly induced in rodent hepatocytes during liver regeneration after two-thirds partial hepatectomy (2/3 PH). Here, we investigated the function of miR-21 in regenerating mouse hepatocytes by inhibiting it with an antisense… CONTINUE READING
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