A miRNA signature associated with human metastatic medullary thyroid carcinoma.

@article{Santarpia2013AMS,
  title={A miRNA signature associated with human metastatic medullary thyroid carcinoma.},
  author={Libero Santarpia and George A. Calin and Liana Adam and Lei Ye and Alfredo Fusco and Serena Giunti and Christina Thaller and Laura Paladini and Xizhen Zhang and Camilo Jim{\'e}nez and Francesco Trimarchi and Adel K. El-Naggar and Robert F Gagel},
  journal={Endocrine-related cancer},
  year={2013},
  volume={20 6},
  pages={
          809-23
        }
}
MicroRNAs (miRNAs) represent a class of small, non-coding RNAs that control gene expression by targeting mRNA and triggering either translational repression or RNA degradation. The objective of our study was to evaluate the involvement of miRNAs in human medullary thyroid carcinoma (MTC) and to identify the markers of metastatic cells and aggressive tumour behaviour. Using matched primary and metastatic tumour samples, we identified a subset of miRNAs aberrantly regulated in metastatic MTC… CONTINUE READING

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