A miR-155–Peli1–c-Rel pathway controls the generation and function of T follicular helper cells

Abstract

MicroRNA (miRNA) deficiency impairs the generation of T follicular helper (Tfh) cells, but the contribution of individual miRNAs to this phenotype remains poorly understood. In this study, we performed deep sequencing analysis of miRNAs expressed in Tfh cells and identified a five-miRNA signature. Analyses of mutant mice deficient of these miRNAs revealed… (More)
DOI: 10.1084/jem.20160204

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