A mex3 homolog is required for differentiation during planarian stem cell lineage development

@inproceedings{Zhu2015AMH,
  title={A mex3 homolog is required for differentiation during planarian stem cell lineage development},
  author={Shu Jun Zhu and Stephanie E. Hallows and Ko W. Currie and Changjiang Xu and Bret J Pearson and Marianne E Bronner},
  booktitle={eLife},
  year={2015}
}
Neoblasts are adult stem cells (ASCs) in planarians that sustain cell replacement during homeostasis and regeneration of any missing tissue. While numerous studies have examined genes underlying neoblast pluripotency, molecular pathways driving postmitotic fates remain poorly defined. In this study, we used transcriptional profiling of irradiation-sensitive and irradiation-insensitive cell populations and RNA interference (RNAi) functional screening to uncover markers and regulators of… CONTINUE READING
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