A methylation-phosphorylation switch determines Sox2 stability and function in ESC maintenance or differentiation.

@article{Fang2014AMS,
  title={A methylation-phosphorylation switch determines Sox2 stability and function in ESC maintenance or differentiation.},
  author={Lan Fang and L Zhang and Wei Wei and Xueling Jin and Ping Wang and Yufeng Tong and Jiwen Li and James Xianxing Du and Jiemin Wong},
  journal={Molecular cell},
  year={2014},
  volume={55 4},
  pages={
          537-51
        }
}
Sox2 is a key factor for maintaining embryonic stem cell (ESS) pluripotency, but little is known about its posttranslational regulation. Here we present evidence that the precise level of Sox2 proteins in ESCs is regulated by a balanced methylation and phosphorylation switch. Set7 monomethylates Sox2 at K119, which inhibits Sox2 transcriptional activity and induces Sox2 ubiquitination and degradation. The E3 ligase WWP2 specifically interacts with K119-methylated Sox2 through its HECT domain to… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 43 CITATIONS

SETD7 Regulates the Differentiation of Human Embryonic Stem Cells

VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

PHF20L1 antagonizes SOX2 proteolysis triggered by the MLL1/WDR5 complexes

  • Laboratory Investigation
  • 2018
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Phosphorylation Modulates the Subcellular Localization of SOX11

  • Front. Mol. Neurosci.
  • 2018
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

A CDC20-APC/SOX2 Signaling Axis Regulates Human Glioblastoma Stem-like Cells.

  • Cell reports
  • 2015
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

Readout of epigenetic modifications.

  • Annual review of biochemistry
  • 2013
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Histone methylation: a dynamic mark in health, disease and inheritance

  • Nature Reviews Genetics
  • 2012
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Control of the embryonic stem cell state

R. A. Young
  • Cell 144, 940–954.
  • 2011
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL