A methylated phosphate group and four amide-linked acyl chains in leptospira interrogans lipid A. The membrane anchor of an unusual lipopolysaccharide that activates TLR2.

@article{QueGewirth2004AMP,
  title={A methylated phosphate group and four amide-linked acyl chains in leptospira interrogans lipid A. The membrane anchor of an unusual lipopolysaccharide that activates TLR2.},
  author={Nanette L S Que-Gewirth and Anthony A. Ribeiro and Suzanne R. Kalb and Robert J. Cotter and Dieter Bulach and Ben Adler and Isabelle Saint Girons and Catherine Werts and Christian R. H. Raetz},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 24},
  pages={25420-9}
}
Leptospira interrogans differs from other spirochetes in that it contains homologs of all the Escherichia coli lpx genes required for the biosynthesis of the lipid A anchor of lipopolysaccharide (LPS). LPS from L. interrogans cells is unusual in that it activates TLR2 rather than TLR4. The structure of L. interrogans lipid A has now been determined by a combination of matrix-assisted laser desorption ionization time-of-flight mass spectrometry, NMR spectroscopy, and biochemical studies. Lipid A… CONTINUE READING
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