A methylated oligonucleotide induced methylation of GSTP1 promoter and suppressed its expression in A549 lung adenocarcinoma cells.

@article{Ishii2004AMO,
  title={A methylated oligonucleotide induced methylation of GSTP1 promoter and suppressed its expression in A549 lung adenocarcinoma cells.},
  author={T. Koryu Ishii and Mina Fujishiro and Michiaki Masuda and Shinji Teramoto and Takeshi Matsuse},
  journal={Cancer letters},
  year={2004},
  volume={212 2},
  pages={211-23}
}
Glutathione S-transferase P1 (GSTP1) belongs to xenobiotic enzymes, and is supposed to contribute to chemoresistance. Though it was reported that GSTP1 gene is suppressed by cytosine-guanine (CpG) island methylation of its promoter, this promoter is not strongly methylated and GSTP1 protein is highly expressed in lung cancer. We intended to induce methylation of GSTP1 CpG island by using a methylated sense oligonucleotide complementary to this region. When we transduced the methylated… CONTINUE READING