A method to quantitate the relative initiating and promoting potencies of hepatocarcinogenic agents in their dose-response relationships to altered hepatic foci.

@article{Pitot1987AMT,
  title={A method to quantitate the relative initiating and promoting potencies of hepatocarcinogenic agents in their dose-response relationships to altered hepatic foci.},
  author={Henry C. Pitot and Thomas L. Goldsworthy and Seana Moran and Wayne Kennan and Howard Perry Glauert and Robert R. Maronpot and Harold Campbell},
  journal={Carcinogenesis},
  year={1987},
  volume={8 10},
  pages={1491-9}
}
The relative response to various initiating doses of diethylnitrosamine (DEN) and dimethylbenz[a]anthracene of the induction of numbers and size (vol. % of liver) of altered hepatic foci (AHF) in livers of adult female rats of the Sprague-Dawley and Fischer 344 (F-344) strains was studied by methods of quantitative stereology in the presence and absence of the promoting agent, phenobarbital (PB, 0.05% in the diet). In all cases, a relatively linear response with dose, even at the lowest doses… CONTINUE READING

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