A method to quantify co-localization in biological images

@article{Zhu2016AMT,
  title={A method to quantify co-localization in biological images},
  author={Shiwen Zhu and Roy E. Welsch and Paul Matsudaira},
  journal={2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)},
  year={2016},
  pages={3887-3890}
}
Quantitative co-localization analysis with fluorescent microscopy is a common approach to assess the spatial co-ordination of molecules and thus to understand their functions in biological processes. However, the co-localization analysis results might not be consistent due to various imaging conditions and different quantification methods used. We propose a novel method to separate a co-localization event into two aspects: co-occurrence and intensity correlation, which are usually combined as… CONTINUE READING

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