A method to estimate treatment efficacy among latent subgroups of a randomized clinical trial.

  title={A method to estimate treatment efficacy among latent subgroups of a randomized clinical trial.},
  author={Lily L Altstein and Gang Li and Robert M. Elashoff},
  journal={Statistics in medicine},
  volume={30 7},
Subgroup analysis arises in clinical trials research when we wish to estimate a treatment effect on a specific subgroup of the population distinguished by baseline characteristics. Many trial designs induce latent subgroups such that subgroup membership is observable in one arm of the trial and unidentified in the other. This occurs, for example, in oncology trials when a biopsy or dissection is performed only on subjects randomized to active treatment. We discuss a general framework to… CONTINUE READING

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