• DOI:10.1016/s0021-9258(18)43072-4
Corpus ID: 31665048

A method for the rapid determination of alkaline phosphates with five cubic millimeters of serum.

@article{Bessey1946AMF,
  title={A method for the rapid determination of alkaline phosphates with five cubic millimeters of serum.},
  author={O. Bessey and O. H. Lowry and M. J. Brock},
  journal={The Journal of biological chemistry},
  year={1946},
  volume={164},
  pages={
          321-9
        }
}

• O. Bessey, O. H. Lowry, M. J. Brock
• Published 1946
• Chemistry, Medicine
• The Journal of biological chemistry

The alkaline phosphatase of the serum increases early and markedly in rickets and returns completely to normal only after healing is complete. Because of this fact, serum phosphatase is the most satisfactory index now known for the detection of this deficiency. The phosphatase activity of serum is not strictly specific in this respect and has also proved clinically useful in a number of other pathological states; e.g., Paget’s disease, hyperparathyroidism, liver disease, etc. In connection wit… Expand

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