A method for the generation of glycoprotein mimetics.

  title={A method for the generation of glycoprotein mimetics.},
  author={Haitian Liu and Lei Wang and Ansgar Brock and C. -H. Wong and Peter G. Schultz},
  journal={Journal of the American Chemical Society},
  volume={125 7},
A general method for preparing glycoprotein mimetics with defined glycan structure using the Z domain protein as an example is reported. An unnatural amino acid containing the keto group was site-specifically incorporated into a target protein, Z domain, in response to the amber nonsense codon with high translational fidelity and efficiency. An aminooxy saccharide derivative was then selectively coupled to this genetically encoded keto group. The resulting saccharide core was elaborated to a… CONTINUE READING
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