A method for the assessment of disease associations with single-nucleotide polymorphism haplotypes and environmental variables in case-control studies.

@article{Zhao2003AMF,
  title={A method for the assessment of disease associations with single-nucleotide polymorphism haplotypes and environmental variables in case-control studies.},
  author={Lue Ping Zhao and Shuying Sue Li and Najma Khalid},
  journal={American journal of human genetics},
  year={2003},
  volume={72 5},
  pages={1231-50}
}
The rough draft of the human genome map has been used to identify most of the functional genes in the human genome, as well as to identify nucleotide variations, known as "single-nucleotide polymorphisms" (SNPs), in these genes. By use of advanced biotechnologies, researchers are beginning to genotype thousands of SNPs from biological samples. Among the many possible applications, one of them is the study of SNP associations with complex human diseases, such as cancers or coronary heart… CONTINUE READING