A method for reducing the time required to match protein sequences with tandem mass spectra.

@article{Craig2003AMF,
  title={A method for reducing the time required to match protein sequences with tandem mass spectra.},
  author={Robertson Craig and Ronald C. Beavis},
  journal={Rapid communications in mass spectrometry : RCM},
  year={2003},
  volume={17 20},
  pages={
          2310-6
        }
}
An algorithm for reducing the time necessary to match a large set of peptide tandem mass spectra with a list of protein sequences is described. This algorithm breaks the process into multiple steps. A rapid survey step identifies all protein sequences that are reasonable candidates for a match with a set of tandem mass spectra. These candidates are then used as models, which are refined by detailed analysis of the set of tandem mass spectra for evidence of incomplete enzymatic hydrolysis, non… CONTINUE READING

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