A method for evaluating the effects of ligands upon Gs protein-coupled receptors using a recombinant melanophore-based bioassay.

@article{Potenza1992AMF,
  title={A method for evaluating the effects of ligands upon Gs protein-coupled receptors using a recombinant melanophore-based bioassay.},
  author={Marc N. Potenza and Gerard F. Graminski and Michael R. Lerner},
  journal={Analytical biochemistry},
  year={1992},
  volume={206 2},
  pages={315-22}
}
As an increasing number of medically important receptors that couple to stimulatory guanine nucleotide (Gs) proteins are isolated and cloned, there is an equally escalating need for methods to rapidly and reproducibly evaluate potential ligands for their properties as agonists or antagonists. Recently, a bioassay that can quickly and accurately determine the effects of numerous chemicals on a beta 1-like adrenergic receptor (AR) endogenous to melanophores derived from Xenopus laevis was… CONTINUE READING

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