A method for evaluating drug effects on intermittent claudication using a treadmill in rats with unilateral hindlimb artery occlusion.

@article{Orito2004AMF,
  title={A method for evaluating drug effects on intermittent claudication using a treadmill in rats with unilateral hindlimb artery occlusion.},
  author={Kensuke Orito and Masami Kishi and Hiroyuki Fujiki and Toru Nakazawa and Takashi Imaizumi and Yukio Kimura and Toyoki Mori and Toshimi Kambe},
  journal={Journal of pharmacological and toxicological methods},
  year={2004},
  volume={49 1},
  pages={25-9}
}
INTRODUCTION We have developed an in vivo experimental model for evaluating peripheral arterial insufficiency and predicting the efficacy of drugs on intermittent claudication (IC). We found that rats that had been running normally on a treadmill developed a gait disturbance when a hindlimb artery was unilaterally occluded. We hypothesized that the distance run before gait disturbance developed (DGD) in rats with occlusion of a hindlimb artery might be an appropriate index of the severity of… CONTINUE READING