A method for estimating within-individual variability in clearance and in volume of distribution from standard bioavailability studies

Abstract

Bioavailability studies are commonly undertaken, and most, because they involve subjects taking repeated doses of a drug, contain information on intraindividual variability in pharmacokinetics. However, because in such studies bioavailability itself is unknown, it is difficult to resolve which pharmacokinetic parameters vary within individuals. A… (More)
DOI: 10.1007/BF01062331

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