A method for estimating the probability of adverse drug reactions

@article{Naranjo1981AMF,
  title={A method for estimating the probability of adverse drug reactions},
  author={Claudio A. Naranjo and Usoa E. Busto and E. M. Sellers and Paul Sandor and I. Ruiz and E. A. O'Donnell Roberts and Eva Janecek and C. Domecq and David J Greenblatt},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1981},
  volume={30}
}
The estimation of the probability that a drug caused an adverse clinical event is usually based on clinical judgment. Lack of a method for establishing causality generates large between‐raters and within‐raters variability in assessment. Using the conventional categories and definitions of definite, probable, possible, and doubtful adverse drug reactions (ADRs), the between‐raters agreement of two physicians and four pharmacists who independently assessed 63 randomly selected alleged ADRs was… 
A new method for assessing drug causation provided agreement with experts' judgment.
Understanding and assessing adverse drug reactions.
  • R. Howland
  • Medicine
    Journal of psychosocial nursing and mental health services
  • 2011
TLDR
A systematic and validated method for estimating the probability of an ADR has been described by Naranjo et al. and solicits answers to 10 questions; the total score is then used to quantify the probabilities of anADR.
Consistency of assessment of adverse drug reactions in psychiatric hospitals: A comparison of an algorithmic and an empirical approach
TLDR
Empirical ratings were found to be reliable over time due to homogeneous use of criteria by project raters, and probability ratings based on the empirical method were nonspecific, due to conventional criteria applied in the project.
An Investigation of Disagreement in Causality Assessment of Adverse Drug Reactions
TLDR
Comparability between assessors was found to be ‘fair’ or less for the ADR causality assessment methods examined in this study, and the high level of disagreement in the results produced using the assessment scales question the robustness of causality assessments.
Comparison of two recently published algorithms for assessing the probability of adverse drug reactions.
TLDR
While ASS is somewhat more complex than APS both are equally reliable and will give very similar conclusions regarding the probability of ADRs, the results suggest that such algorithms must be used if the clinical assessment ofADRs is to become acceptably reliable.
Reliability of adverse drug reaction assessment in psychiatric inpatients
TLDR
Agreement on total judgment was comparable to results from similar studies in the literature using various algorithms, but in contrast to all these studies a higher percent of agreement was obtained with the use of the conventional criteria in this study.
Computerized comparison of six adverse drug reaction assessment procedures
TLDR
This work eliminated between‐raters variability by computer simulation of 1134 ADRs (including all the possible combinations of criteria currently used) and by automatic rating using different algorithms adapted from six published methods.
Comparison of the Bayesian approach and a simple algorithm for assessment of adverse drug events *
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Comparison of two recently published algorithms for assessing the probability of adverse drug reactions.
TLDR
While ASS is somewhat more complex than APS both are equally reliable and will give very similar conclusions regarding the probability of ADRs, the results suggest that such algorithms must be used if the clinical assessment ofADRs is to become acceptably reliable.
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