A method for detecting recent selection in the human genome from allele age estimates.

@article{Toomajian2003AMF,
  title={A method for detecting recent selection in the human genome from allele age estimates.},
  author={Christopher Toomajian and Richard S. Ajioka and Lynn B. Jorde and James P. Kushner and Martin Kreitman},
  journal={Genetics},
  year={2003},
  volume={165 1},
  pages={287-97}
}
Mutations that have recently increased in frequency by positive natural selection are an important component of naturally occurring variation that affects fitness. To identify such variants, we developed a method to test for recent selection by estimating the age of an allele from the extent of haplotype sharing at linked sites. Neutral coalescent… CONTINUE READING