A method for assessing the microvasculature in a murine tumor model using contrast-enhanced ultrasonography.

@article{Loveless2008AMF,
  title={A method for assessing the microvasculature in a murine tumor model using contrast-enhanced ultrasonography.},
  author={Mary E. Loveless and Xia Li and Jessica Huamani and Andrej Lyshchik and Benoit M. Dawant and Dennis Hallahan and John C. Gore and Thomas E. Yankeelov},
  journal={Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine},
  year={2008},
  volume={27 12},
  pages={1699-709}
}
OBJECTIVE The purpose of this study was to develop a method for assessing tumor vascularity in a preclinical model of breast cancer using contrast-enhanced ultrasonography. METHODS Eight mice were injected with 67NR breast cancer cells on their hind limbs and imaged with ultrasonography 8 days later. Mice were injected with an ultrasound contrast agent (UCA), and a sequence of images of the resultant backscattered echoes was recorded before and after high-power "destruction" pulses for each… CONTINUE READING