A metalloproteinase inhibitor as an inhibitor of neovascularization.

  title={A metalloproteinase inhibitor as an inhibitor of neovascularization.},
  author={Marsha A Moses and Robert Langer},
  journal={Journal of cellular biochemistry},
  volume={47 3},
Metalloproteinases and their endogenous inhibitors are key components of an enzyme system which is important in a number of fundamental biochemical and cellular processes. Our recent work has focused on the role of a particular metalloproteinase, collagenase, and the role of an endogenous inhibitor of this enzyme in the control of neovascularization. The proteolytic degradation of extracellular matrix components by capillary endothelial cells (EC) has been shown to be one of the key… CONTINUE READING

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