A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

@article{Black1997AMD,
  title={A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells},
  author={R. Black and C. Rauch and C. Kozlosky and J. Peschon and J. Slack and M. Wolfson and Beverly J. Castner and Kim L. Stocking and P. Reddy and S. Srinivasan and N. Nelson and N. Boiani and Kenneth A. Schooley and M. Gerhart and R. Davis and Jeffrey N. Fitzner and Richard S. Johnson and R. Paxton and C. March and Douglas Pat Cerretti},
  journal={Nature},
  year={1997},
  volume={385},
  pages={729-733}
}
Mammalian cells proteolytically release (shed) the extracellular domains of many cell-surface proteins1. Modification of the cell surface in this way can alter the cell's responsiveness to its environment2 and release potent soluble regulatory factors3. The release of soluble tumour-necrosis factor-α (TNF-α) from its membrane-bound precursor4,5 is one of the most intensively studied shedding events because this inflammatory cytokine is so physiologically important6,7. The inhibition of TNF… Expand
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