A metalloprotease disintegrin that controls cell migration in Caenorhabditis elegans.

@article{Nishiwaki2000AMD,
  title={A metalloprotease disintegrin that controls cell migration in Caenorhabditis elegans.},
  author={Kiyoji Nishiwaki and Naoki Hisamoto and Kunihiro Matsumoto},
  journal={Science},
  year={2000},
  volume={288 5474},
  pages={2205-8}
}
In Caenorhabditis elegans, the gonad acquires two U-shaped arms by the directed migration of its distal tip cells (DTCs) along the body wall basement membranes. Correct migration of DTCs requires the mig-17 gene, which encodes a member of the metalloprotease-disintegrin protein family. The MIG-17 protein is secreted from muscle cells of the body wall and localizes in the basement membranes of gonad. This localization is dependent on the disintegrin-like domain of MIG-17 and its catalytic… CONTINUE READING

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