A metabonomic approach to early prognostic evaluation of experimental sepsis by 1H NMR and pattern recognition

@article{Lin2009AMA,
  title={A metabonomic approach to early prognostic evaluation of experimental sepsis by 1H NMR and pattern recognition},
  author={Zhong-ying Lin and Ping-bo Xu and Shi-kai Yan and Hai-bing Meng and Gen-jin Yang and Weixing Dai and Xin-ru Liu and Jin-bao Li and Xiaoming Deng and Weidong Zhang},
  journal={NMR in biomedicine},
  year={2009},
  volume={22 6},
  pages={
          601-8
        }
}
This study proposes an NMR-based metabonomic approach to early prognostic evaluation of sepsis. Forty septic rats receiving cecal ligation and puncture (CLP) were divided into the surviving group and nonsurviving group on day 6, while 20 sham-operated rats served as the control group. Serum samples were collected from septic and sham-operated rats at 12 h after surgery and analyzed using (1)H NMR spectroscopy. Orthogonal partial least squares (OPLS) were applied and showed clustering according… CONTINUE READING

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