A metabolomic approach for diagnosis of experimental sepsis

  title={A metabolomic approach for diagnosis of experimental sepsis},
  author={Jose L. Izquierdo-Garc{\'i}a and N. Nin and Jes{\'u}s Ru{\'i}z-Cabello and Yeny Rojas and Marta Sevilha de Paula and Sonia L{\'o}pez-Cuenca and Luis Morales and Leticia Mart{\'i}nez-Caro and Pilar Fern{\'a}ndez-Segoviano and Andr{\'e}s Esteban and J. A. Lorente},
  journal={Intensive Care Medicine},
The search for reliable diagnostic biomarkers of sepsis remains necessary. Assessment of global metabolic profiling using quantitative nuclear magnetic resonance (NMR)-based metabolomics offers an attractive modern methodology for fast and comprehensive determination of multiple circulating metabolites and for defining the metabolic phenotype of sepsis. To develop a novel NMR-based metabolomic approach for diagnostic evaluation of sepsis. Male Sprague–Dawley rats (weight 325–375 g) underwent… CONTINUE READING
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