A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas

@inproceedings{Bean2016AMS,
  title={A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas},
  author={Gregory R. Bean and Jeff Charles Kremer and Bethany C Prudner and Aaron D Schenone and Juo-Chin Yao and Matthew Bailey Schultze and David Y-S Chen and Munir R. Tanas and Douglas Ray Adkins and John Stephen Bomalaski and Brian P. Rubin and Loren Scott Michel and Brian A Van Tine},
  booktitle={Cell Death and Disease},
  year={2016}
}
Sarcomas comprise a large heterogeneous group of mesenchymal cancers with limited therapeutic options. When treated with standard cytotoxic chemotherapies, many sarcomas fail to respond completely and rapidly become treatment resistant. A major problem in the investigation and treatment of sarcomas is the fact that no single gene mutation or alteration has been identified among the diverse histologic subtypes. We searched for therapeutically druggable targets that are common to a wide range of… CONTINUE READING
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