A metabolic perturbation by U0126 identifies a role for glutamine in resveratrol-induced cell death.

@article{Freeman2011AMP,
  title={A metabolic perturbation by U0126 identifies a role for glutamine in resveratrol-induced cell death.},
  author={Michael R. Freeman and Jayoung Kim and Michael Phillip Lisanti and Dolores Di Vizio},
  journal={Cancer biology & therapy},
  year={2011},
  volume={12 11},
  pages={966-77}
}
Recent evidence has identified substantial overlap between metabolic and oncogenic biochemical pathways, suggesting novel approaches to cancer intervention. For example, cholesterol lowering statins and the antidiabetes medication metformin both act as chemopreventive agents in prostate and other cancers. The natural compound resveratrol has similar properties: increasing insulin sensitivity, suppressing adipogenesis, and inducing apoptotic death of cancer cells in vitro. However, in vivo tumor… CONTINUE READING
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