A metabolic engineering strategy for producing conjugated linoleic acids using the oleaginous yeast Yarrowia lipolytica

@inproceedings{Imatoukene2017AME,
  title={A metabolic engineering strategy for producing conjugated linoleic acids using the oleaginous yeast Yarrowia lipolytica},
  author={Nabila Imatoukene and Jonathan Verbeke and Athanasios Beopoulos and Abdelghani Idrissi Taghki and Brigitte Thomasset and C. -O. Sarde and Maurice Nonus and Jean-Marc Nicaud},
  booktitle={Applied Microbiology and Biotechnology},
  year={2017}
}
Conjugated linoleic acids (CLAs) have been found to have beneficial effects on human health when used as dietary supplements. However, their availability is limited because pure, chemistry-based production is expensive, and biology-based fermentation methods can only create small quantities. In an effort to enhance microbial production of CLAs, four genetically modified strains of the oleaginous yeast Yarrowia lipolytica were generated. These mutants presented various genetic modifications… CONTINUE READING
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