• DOI:10.1080/17425247.2019.1653852
Corpus ID: 199505274

A meta-opinion: cannabinoids delivered to oral mucosa by a spray for systemic absorption are rather ingested into gastro-intestinal tract: the influences of fed / fasting states

@article{Itin2019AMC,
  title={A meta-opinion: cannabinoids delivered to oral mucosa by a spray for systemic absorption are rather ingested into gastro-intestinal tract: the influences of fed / fasting states},
  author={Constantin Itin and A. Domb and A. Hoffman},
  journal={Expert Opinion on Drug Delivery},
  year={2019},
  volume={16},
  pages={1031 - 1035}
}

• Constantin Itin, A. Domb, A. Hoffman
• Published 2019
• Medicine
• Expert Opinion on Drug Delivery

ABSTRACT Introduction: Sativex® spray is clinically utilized to deliver delta9-tetrahydrocannabinol and cannabidiol to oral mucosa for systemic absorption. We challenge the consensus that the mechanism of absorption following the oro-mucosal application occurs via the buccal tissue. Areas covered: Correctness of the consensus of this absorption pathway arose when reviewing publications regarding the influence fed versus fasting states have on pharmacokinetics of these cannabinoids administered… Expand

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