A meta-analytic approach to estimating nocebo effects in neuropathic pain trials

  title={A meta-analytic approach to estimating nocebo effects in neuropathic pain trials},
  author={Dimitrios Papadopoulos and Dimos-Dimitrios D Mitsikostas},
  journal={Journal of Neurology},
The development of non-specific adverse effects following the administration of an active or inert substance is referred to as nocebo phenomenon. We aimed to estimate the frequency and severity of nocebo responses in clinical trials of pharmacological treatments for neuropathic pain. A systematic Medline search for all randomized, placebo-controlled neuropathic pain trials published between 2000 and 2010 was carried out. Meta-analysis of the frequency of nocebo responses was performed by… CONTINUE READING


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