Corpus ID: 201110312

A meta-analysis on association of CYP 2 E 1 rs 2031920 and rs 3813867 polymorphisms with breast cancer risk

@inproceedings{Chong2018AMO,
  title={A meta-analysis on association of CYP 2 E 1 rs 2031920 and rs 3813867 polymorphisms with breast cancer risk},
  author={Eric Tzyy Jiann Chong and Lucky Poh Wah Goh and Ping-Chin Lee},
  year={2018}
}
Breast cancer remains a challenging disease globally due to its heterogeneity and complexity, with an annual increase rate of 3.1%. Cytochrome P450 2E1 (CYP2E1) rs2031920 and rs3813867 polymorphisms that reside in the 5’-flanking promoter region of the gene are in a complete linkage disequilibrium and have been associated with breast cancer risk, but the findings are inconsistent and inconclusive. Therefore, we investigated the association of the CYP2E1 rs2031920 and rs3813867 polymorphisms… Expand

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TLDR
This study showed that the c1/c2 genotype or subjects with at least one c2 allele in CYP2E1 rs3813867 SNP had significantly increased almost 1.8-fold higher breast cancer risk in Malaysian women overall. Expand
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