A meta-analysis of threats to valid clinical inference in preclinical research of sunitinib

Abstract

Poor study methodology leads to biased measurement of treatment effects in preclinical research. We used available sunitinib preclinical studies to evaluate relationships between study design and experimental tumor volume effect sizes. We identified published animal efficacy experiments where sunitinib monotherapy was tested for effects on tumor volume… (More)
DOI: 10.7554/eLife.08351

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