A meta-analysis of the neuropsychological sequelae of HIV infection

  title={A meta-analysis of the neuropsychological sequelae of HIV infection},
  author={Mark A. Reger and Robert Ethol Welsh and Jill Razani and David J. Martin and Kyle Brauer Boone},
  journal={Journal of the International Neuropsychological Society},
  pages={410 - 424}
  • M. Reger, R. Welsh, K. Boone
  • Published 1 March 2002
  • Psychology
  • Journal of the International Neuropsychological Society
This meta-analysis summarizes the broad spectrum of neuropsychological research on HIV disease across a sample of 41 primary studies and an aggregate of 8,616 participants for 10 major neuropsychological ability areas. Analyses of the course of cognitive decline within and across Centers for Disease Control classifications reveals statistically significant cognitive deficits from asymptomatic HIV to AIDS. Effect sizes (Cohen, 1988) were calculated to reflect between-group (asymptomatic… 

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[Characteristics of the neuropsychological performance in patients with HIV infection].

It is considered that the characteristics of the neuropsychological performance observed in the early stages of the infection cannot be used as reliable predictors of more severe future neuroPsychological alterations characteristic of the most advanced phases of HIV infection.

Impaired Neurocognitive Performance and Mortality in HIV: Assessing the Prognostic Value of the HIV-Dementia Scale

In the absence of an AIDS-defining condition, NCI, particularly in the executive/attention domain, is an independent prognostic marker of mortality in a diverse HIV-positive cohort, highlighting the clinical utility of brief cognitive screening measures in this population.

Heterogeneity of Neuropsychological Impairment in HIV Infection: Contributions from Mild Cognitive Impairment

Following a review of diagnostic methods and challenges in the study of HAND, the literature regarding conventional and empirical subtypes of MCI and HAND are summarized and directions for future research regarding neurocognitive heterogeneity in HIV infection are identified.

Depression and Neurocognitive Performance in Portuguese Patients Infected with HIV

Despite good patient adherence to treatment (HAART and antidepressive) and good immune status, the prevalence of HAND and depression are high and suggest a significant relation between severity of depression and cognitive functioning.

Cognitive Functioning in Adults Aging with HIV: A Cross-Sectional Analysis of Cognitive Subtypes and Influential Factors.

There are not unique cognitive subtypes in HIV, but rather a subset of individuals who exhibit globally normal performance and those with below average performance, which suggest that older age and the related cardiovascular comorbidities of both aging and HIV medications should be considered in future studies.

The HIV Dementia Scale: Predictive power in mild dementia and HAART




Neuropsychological functioning of HIV-infected males.

A Meta-Analysis of previous HIV-related neuropsychological research and new data from a study with methodological improvements over early investigations concludes that subjects with AIDS performed worse than other groups on all tests, with 80% showing clinical impairment.

WHO Neuropsychiatric AIDS study, cross-sectional phase II. Neuropsychological and neurological findings.

Data suggest that the risk of subtle cognitive deficits may be increased in asymptomatic stages of HIV-1 infection, however, these deficits are not associated with neurologic changes and do not seem to affect subjects' social functioning.

Neuropsychological performance and CD4 levels in HIV-1 asymptomatic infection.

The data suggest that factors other than absolute levels of immunosuppression as expressed by CD4 levels alone, appear to be responsible for the deficits observed in HIV+ asymptomatic patients.

Cognitive impairment in asymptomatic stages of HIV infection. A longitudinal study.

The presence of cognitive abnormalities in early HIV infection is predictive of a further decrease in cognitive functioning and faster progression to AIDS-this latter reflected by a faster rate of decline in the number of CD4+ cells and by an increase in positivity of serum p24 antigen.

Neuropsychometric performance of asymptomatic HIV-infected subjects.

It is concluded that neuropsychometric performance of asymptomatic HIV-positive subjects cannot be distinguished from that of high-risk HIV-negative subjects by a battery of traditional neuropsychological tests.

Metacognition in HIV-1 seropositive asymptomatic individuals: self-ratings versus objective neuropsychological performance. Multicenter AIDS Cohort Study (MACS).

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Effects of Immunosuppression and Disease Severity Upon Neuropsychological Function in HIV Infection

The data suggest that cognitive impairment in AIDS is unlikely due to independent contributions of immunosuppression and illness, rather neurobehavioral deficits are more likely attributable to a combination of the two.

Depression and neuropsychological performance in asymptomatic HIV infection.

The data indicate that the subtle neuropsychological abnormalities observed in some asymptomatic HIV-seropositive subjects cannot be attributed to depression, and indicate the advantages of a multifaceted approach to assessment of depression.

Neuropsychological performance in HIV‐1‐infected homosexual men

Results from this study support the hypothesis that the frequency of neuropsychological abnormalities in asymptomatic HIV-1-infected homosexual men is low, and not statistically different from that of seronegative controls.

Neuropsychological studies of asymptomatic Human Immunodeficiency Virus-Type-1 infected individuals

Overall, the differences observed between median rates of impairment for asymptomatic and seronegative groups provided the clearest indication of deficits in asymPTomatics.